Substance Use Disorder | Jianing Wang

A spatial capture-recapture approach for estimating opioid use disorder prevalence in small areas using administrative data

Working Paper

Jianing Wang, Shariq Mohammed, Laura F. White, David Kline

Massachusetts prevalence of Opioid Use Disorder estimation revisited: Comparing a Bayesian approach to standard capture-recapture methods

Working Paper abstract Accurate estimation of the prevalence of people with opioid use disorder (OUD) is critical to the success of treatment and resource planning. Various indirect estimation approaches have been used but are subject to issues related to data availability and infrastructure.

Jianing Wang, Nathan Doogan, Katherine Thompson, Dana Bernson, Daniel Feaster, Jennifer Villani, Redonna Chandler, Laura F. White, David Kline, Joshua A. Barocas

On the estimation of population size – A comparison of capture-recapture and multiplier-benchmark methods

Working Paper

Jianing Wang, David Kline, Laura F. White

The prevalence of opioid use disorder in Kentucky’s counties: A two-year multi-sample capture-recapture analysis

abstract Background Kentucky has one of the highest opioid overdose mortality rates in the United States. Accurate estimates of people with opioid use disorder (OUD) are critical to plan for the scope of interventions required to reduce overdose and opioid misuse.

Katherine Thompson, Joshua A Barocas, Chris Delcher, Jungjun Bae, Lindsey Hammerslag, Jianing Wang, Redonna Chandler, Jennifer Villani, Sharon Walsh, Jeffery Talbert

Opioid Use Disorder Among Ohio’s Medicaid Population: Prevalence Estimates From 19 Counties Using a Multiplier Method

abstract The decades-long overdose epidemic in the United States is driven by opioid misuse. Overdoses commonly, although not exclusively, occur in individuals with opioid use disorder (OUD). To allocate adequate resources and develop appropriately scaled public health responses, accurate estimation of the prevalence of OUD is needed.

Nathan J Doogan, Aimee Mack, Jianing Wang, Dushka Crane, Rebecca Jackson, Mary Applegate, Jennifer Villani, Redonna Chandler, Joshua A Barocas

Population-level impact of initiating pharmacotherapy and linking to care people with opioid use disorder at inpatient medically managed withdrawal programs: an effectiveness and cost-effectiveness analysis

abstract Background and Aims Medications for opioid use disorder (MOUD) are shown to reduce opioid use and the risk of overdose. People with opioid use disorder (OUD) who exit inpatient medically managed withdrawal programs (detox) without initiating MOUD and linking to outpatient care have high rates of overdose.

Alexandra Savinkina, Rajapaksha WMA Madushani, Golnaz Eftekhari Yazdi, Jianing Wang, Joshua A Barocas, Jake R Morgan, Sabrina A Assoumou, Alexander Y Walley, Benjamin P Linas, Sean M Murphy

Modeling the cost-effectiveness and impact on fatal overdose and initiation of buprenorphine–naloxone treatment at syringe service programs

abstract Aim To estimate the number of treatment initiations, averted fatal opioid overdoses and the cost-effectiveness associated with offering buprenorphine–naloxone (buprenorphine) treatment on-site within existing syringe service programs (SSPs) in Massachusetts, USA.

Joëlla W Adams, Alexandra Savinkina, Aaron Fox, Czarina N Behrends, Rajapaksha WMA Madushani, Jianing Wang, Avik Chatterjee, Alexander Y Walley, Joshua A Barocas, Benjamin P Linas

Empirical Calibration of a Simulation Model of Opioid Use Disorder

abstract Simulation models of opioid use disorder (OUD) aim at evaluating the impact of different treatment strategies on population-level outcomes. Researching Effective Strategies to Prevent Opioid Death (RESPOND) is a dynamic population state-transition model that simulates Massachusetts (MA) OUD population synthesizing data from the MA Public Health Data Warehouse, published survey studies, and randomized trials.

RWMA Madushani, Jianing Wang, Michelle Weitz, Benjamin Linas, Laura White, Stavroula Chrysanthopoulou

HIV Pre-exposure prophylaxis and buprenorphine at a drug detoxification center during the opioid epidemic: opportunities and challenges

abstract Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) and buprenorphine decrease HIV acquisition. Between November, 2016 - July, 2017, we surveyed persons (N=200) at a drug detoxification center to assess their interest in PrEP and in buprenorphine, and to examine factors associated with such interests.

Sabrina A Assoumou, Samantha M Paniagua, Priscilla Gonzalez, Jianing Wang, Curt G Beckwith, Laura F White, Jessica L Taylor, Kristen Coogan, Jeffrey H Samet, Benjamin P Linas

Outcomes associated with medications for opioid use disorder among persons hospitalized for infective endocarditis

abstract Background Endocarditis, once predominately found in older adults, is increasingly common among younger persons who inject drugs. Untreated opioid use disorder (OUD) complicates endocarditis management. We aimed to determine if rates of overdose and rehospitalization differ between persons with OUD with endocarditis who are initiated on medications for OUD (MOUDs) within 30 days of hospital discharge and those who are not.

Joshua A Barocas, Jake R Morgan, Jianing Wang, Dylan McLoone, Alysse Wurcel, Michael D Stein